Variable Response of Human Cells to Polyinosinic-Polycytidylic Acid

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Variable response of human cells to polyinosinic-polycytidylic acid.

Human cells derived from various organs of a single embryo responded variably to polyinosinic-polycytidylic acid with respect to induction of antiviral resistance and interferon.

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Inhibition of multiplication of Mycobacterium leprae by polyinosinic-polycytidylic acid.

Contrary to the results of an earlier study in which polyinosinic-polycytidylic acid [poly(I:C)] administered intraperitoneally to mice had no effect on multiplication of Mycobacterium leprae in the mouse footpad, the local administration of poly(I:C) every 12 h for 15 doses during logarithmic multiplication was found both to inhibit bacterial multiplication and to produce high tissue levels of...

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The effect of polyinosinic-polycytidylic acid on the immune response of mice to antigenically distinct tumors.

Polyinosinic-polycytidylic acid temporarily inhibits the growth rate of visible, transplanted tumors of both chemical (methylcholanthrene-induced fibrosarcomas) and viral (murine poly orna) origin with nearly equal facility. This effect is dose related and is associated with lymphopenia and death at high doses or following prolonged administration. Polyinosinicpolycytidylic acid produces a vari...

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Uterine Epithelial Cells Specifically Induce Interferon-Stimulated Genes in Response to Polyinosinic-Polycytidylic Acid Independently of Estradiol

Interferon β (IFNβ) is an antiviral cytokine secreted in response to pathogenic exposure that creates a restrictive intracellular environment through the action of downstream interferon-stimulated genes (ISG). The objective of this study was to examine the expression of IFNβ and ISG in both human uterine epithelial cells (UEC) and the ECC-1 uterine epithelial cell line and determine if expressi...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1973

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.3.5.642